How We Built The Company Wire 50
Our ranking methodology, the data behind it, and what we deliberately left out.
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Patronus AI Raises $50 Million to Simulate the Worlds Agents Work In
The AI testing company is moving beyond fixed benchmarks with models that generate changing environments for training and evaluation.
xCures Raises $46 Million to Turn Medical Records Into Decision-Ready Data
The Oakland company is expanding technology that structures fragmented patient information for clinical care, research and regulatory evidence.
Coval Raises $28 Million to Stress-Test Voice and Chat Agents
The former Waymo engineer behind the startup is applying simulation and observability techniques to customer-facing AI systems.
OpenAI Launches Patch the Planet for Open-Source Security
The initiative combines AI-assisted vulnerability research with expert review to find, validate and repair flaws in widely used software.
NewLimit Raises $435 Million to Advance Cellular Reprogramming Medicines
The longevity biotechnology company plans to move its first liver program toward human testing while expanding its discovery platform.
NeoCognition Launches With $40 Million for Agents That Learn on the Job
The new research lab wants software agents to build specialized expertise from experience instead of remaining fixed after training.
Spiral Therapeutics Raises $27 Million and Adds an Inner Ear Partnership
The clinical-stage company will advance its lead hearing program while working with Advanced Bionics on therapies delivered alongside cochlear implants.
Primepoint Labs Discloses $10 Million Seed Round for Construction AI
The San Mateo startup is teaching software to connect drawings, specifications and other building documents before missing details become costly field problems.
Anthropic Previews Claude Mythos With a Security-First Rollout
The general-purpose frontier model is initially limited to selected cybersecurity partners rather than a public API release.
Littlebird Raises $11 Million for a Context-Aware Desktop Assistant
The startup is building an AI memory that reads on-screen text, prepares meeting notes and retrieves information from a user's daily work.
OpenAI Agrees to Acquire AI Security Platform Promptfoo
The open-source testing company will strengthen security evaluation for enterprise agents in OpenAI Frontier.
Braintrust Raises $80 Million to Measure AI Systems in Production
The observability startup reached an $800 million valuation as companies seek better ways to test and improve applications built on language models.
Simile Raises $100 Million to Build AI Simulations of Human Behavior
The Stanford-rooted startup wants digital populations to help organizations test decisions before they affect customers, workers or markets.
OpenAI Launches Frontier to Manage Enterprise AI Agents
The new platform connects agents to company data and tools while adding identity, permissions, evaluation and governance across different agent providers.
